AnalgesiX®

AnalgesiX®

Understanding the Innovative Science Behind our Solution

Understanding Pain

Navigating the Complexity of Chronic Pain

Pain is defined by the International Association for the Study of Pain (IASP) as ‘an unpleasant sensory and emotional experience associated with, or resembling that associated with, actual or potential tissue damage1. The diagnosis and treatment of pain can be challenging particularly in the case of chronic low back pain.

Chronic low back pain is defined as a pain that last at least 3 months. The biopsychosocial understanding of low back pain involves multiple and complex interlinked parameters. To add to the complexity to chronic low back pain, multiple comorbidities such as depression might contribute to or exacerbate the perception of pain.   According to most guidelines, the treatment of chronic low back pain should first start with non pharmacological treatment before introducing pharmacological treatments. The latter have been shown to have limited effectiveness or potential for harm2.

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Discover AnalgesiX®

The Innovative Solutions for Chronic Pain

AnalgesiX® combines the patented science behind our blue light technology with the effects of deep penetrating infrared light to address chronic low back pain.

The mechanism of action of blue light in pain is complex and multifactorial. The skin exposure to blue light is hypothesised to lead to TRPA1 antagonism hence explaining the role in pain modulation3. Blue light stimulation of the light-gated ion channels known as opsins also leads to tissue calcium release therefore supporting muscle function and wound healing4. Blue light stimulates nitric oxide (NO) release in mitochondria subject to inflammation, restoring mitochondrial respiration5,6,7 and triggering antioxidant and analgesic effects in combination with vasodilatation known to support tissue repair and regeneration8.

Infrared (IR) radiation has also been showed to decrease pain levels9 in patients suffering from musculoskeletal disorders. IR stimulates growth factor production and extracellular matrix deposition promoting tissue repair10. IR has also been associated with a reduction in inflammation and restoration of function owing to a deep tissue penetration11.

Check our clinical trials data in the Clinical Trials section for more info.

Innovation at the Forefront of Pain Relief

Pain Modulation

The AnalgesiX® system delivers a combination of blue and infrared radiations with specific parameters that lead to a cascade of anti-inflammatory and anti-oxidation effects, nociception modulation and tissue repair. These effects are hypothesised to significantly decrease musculoskeletal chronic low back pain in adults and improve functionality and quality of life of patients while avoiding the side effects and pitfalls associated with pharmacotherapy.

The hope of a personalised treatment thanks to Artificial Intelligence

In the future, our system will incorporate machine learning and artificial intelligence aimed at adapting and optimising treatment based on each patient's individual data. Over time, the device "learns" from the patient's responses depending on the duration and frequency of session thus offering more personalised and effective treatment.

Safety First

AnalgesiX® technology is designed to provide non-invasive treatment without harmful side effects, providing a peace of mind for both patients and healthcare professionals.

ADVANCED ANALGESIX® TECHNOLOGY

Innovation at the Forefront of Pain Relief

Positioning the Device

Position the AnalgesiX® lumbar belt against your lower back, aligning it with the area of discomfort. The belt's design is intentionally ergonomic, offering a snug fit that targets the source of pain. Adjust the straps to secure the device, ensuring it conforms to your body's contour for maximum comfort and optimal therapeutic impact.

Initiating the Treatment session

Power on the device by pushing the single button press. Open the AnalgesiX® app on your smartphone, which will automatically connect to your device via Bluetooth. Select 'Start Treatment' to begin a 45-minute session. The app will guide you through the process, offering a user-friendly interface for effortless control.

Treatment that let you get on with your daily activities

Once activated, you can go about your daily activities with the AnalgesiX® device discreetly in place. The built-in timer ensures that your session ends after the recommended duration, with an automatic shut-off feature for your convenience. After your session, the app provides a summary of your treatment and tracks your progress over time.

Scientific References

  1. Understanding Pain – International Association for the Study of Pain
  2. Global Burden of Disease Collaborators. “Global, regional, and national burden of low back pain, 1990-2020…” Lancet Rheumatol 2023;5(6):e316-e329.
  3. Costa et al. “A Definition of ‘Flare’ in Low Back Pain…” J Pain 2019;20(11):1267-1275.
  4. Foster NE et al. “Effect of stratified care for low back pain…” Ann Fam Med 2014;12(2):102-111.
  5. Karran EL et al. “Low back pain and the social determinants of health…” Pain 2020;161(11):2476-2493.
  6. Kongsted A et al. “Patients with low back pain had distinct clinical course patterns…” Spine J 2015;15:885-894.
  7. Williams CM et al. “Low back pain and best practice care…” Arch Intern Med 2010;170(3):271-277.
  8. IASP Fact Sheets on Low Back Pain
  9. Gøtzsche PC. “Niels Finsen’s treatment for lupus vulgaris.” J R Soc Med. 2011;104(1):41-2.
  10. Anders JJ, et al. “Low-level light/laser therapy versus photobiomodulation therapy.” Photomed Laser Surg 2015;33:183–4.
  11. Abrisham SM, et al. “Additive effects of low-level laser therapy with exercise on subacromial syndrome.” Clin Rheumatol 2011;30:1341–6.
  12. Bertolucci LE, Grey T. “Clinical analysis of mid-laser versus placebo treatment of arthralgic TMJ degenerative joints.” Cranio 1995;13:26–9.
  13. Ozdemir F, Birtane M, Kokino S. “The clinical efficacy of low-power laser therapy on pain and function in cervical osteoarthritis.” Clin Rheumatol 2001;20:181–4.
  14. Stelian J, et al. “Improvement of pain and disability in elderly patients with degenerative osteoarthritis of the knee treated with narrow-band light therapy.” J Am Geriatr Soc 1992;40:23–6.
  15. Bjordal JM, et al. “A randomised, placebo controlled trial of low level laser therapy for activated Achilles tendinitis with microdialysis measurement of peritendinous prostaglandin E2 concentrations.” Br J Sports Med 2006b;40:76–80.
  16. Stergioulas A, et al. “Effects of low-level laser therapy and eccentric exercises in the treatment of recreational athletes with chronic achilles tendinopathy.” Am J Sports Med 2008;36:881–7.
  17. Vasseljen O Jr, et al. “Low level laser versus placebo in the treatment of tennis elbow.” Scand J Rehabil Med 1992;24:37–42.
  18. Caetano KS, et al. “Phototherapy Improves Healing of Chronic Venous Ulcers.” Photomed Laser Surg 2009.
  19. Gupta AK, et al. “The use of low energy photon therapy (LEPT) in venous leg ulcers.” Dermatol Surg 1998;24:1383–6.
  20. Ozcelik O, et al. “Improved wound healing by low-level laser irradiation after gingivectomy operations.” J Clin Periodontol 2008;35:250–4.
  21. Schubert MM, et al. “A phase III randomized double-blind placebo-controlled clinical trial to determine the efficacy of low level laser therapy for the prevention of oral mucositis in patients undergoing hematopoietic cell transplantation.” Support Care Cancer 2007;15:1145–54.
  22. Basford JR, Sheffield CG, Harmsen WS. Laser therapy: a randomized, controlled trial of the effects of low-intensity Nd:YAG laser irradiation on musculoskeletal back pain. Arch Phys Med Rehabil. 1999;80:647–52
  23. Chow RT, Heller GZ, Barnsley L. The effect of 300 mW, 830 nm laser on chronic neck pain: a double-blind, randomized, placebo-controlled study. Pain. 2006;124:201–10.
  24. Gur A, Sarac AJ, Cevik R, Altindag O, Sarac S. Efficacy of 904 nm gallium arsenide low level laser therapy in the management of chronic myofascial pain in the neck: a double-blind and randomize-controlled trial. Lasers Surg Med. 2004;35:229–35
  25. Leal Junior EC, Lopes-Martins RA, Baroni BM, De Marchi T, Taufer D, Manfro DS, Rech M, Danna V, Grosselli D, Generosi RA, Marcos RL, Ramos L, Bjordal JM. Effect of 830 nm low-level laser therapy applied before high-intensity exercises on skeletal muscle recovery in athletes. Lasers Med Sci 2008a
  26. Leal Junior EC, Lopes-Martins RA, Vanin AA, Baroni BM, Grosselli D, De Marchi T, Iversen VV, Bjordal JM. Effect of 830 nm low-level laser therapy in exercise-induced skeletal muscle fatigue in humans. Lasers Med Sci 2008b
  27. Rochkind S, Leider-Trejo L, Nissan M, Shamir MH, Kharenko O, Alon M. Efficacy of 780-nm laser phototherapy on peripheral nerve regeneration after neurotube reconstruction procedure (double-blind randomized study) Photomed Laser Surg. 2007;25:137–43.
  28. Lampl Y, Zivin JA, Fisher M, Lew R, Welin L, Dahlof B, Borenstein P, Andersson B, Perez J, Caparo C, Ilic S, Oron U. Infrared Laser Therapy for Ischemic Stroke: A New Treatment Strategy. Results of the NeuroThera Effectiveness and Safety Trial-1 (NEST-1) Stroke 2007
  29. Huang YY, Chen AC, Carroll JD, Hamblin MR. Biphasic dose response in low level light therapy. Dose Response. 2009 Sep 1;7(4):358-83. doi: 10.2203/dose-response.09-027.Hamblin. PMID: 20011653; PMCID: PMC2790317.
  30. Natallia E. Uzunbajakava, Desmond J. Tobin, Natalia V. Botchkareva, Christine Dierickx, Peter Bjerring, Godfrey Town Highlighting nuances of blue light phototherapy: mechanisms, safety & benefits considerations. I M C A S W O R L D C O N G R E S S 2 0 2 3 – J A N U A R Y 2 6 T O 2 8
  31. Kokel et al. (2013) Photochemical activation of TRPA1 channels in neurons and animals. Nat Chem Biol. 2013 Apr;9(4):257-63.
  32. Fajardo and Friedrich (2013) Optopharmacology: a light switch for pain. Nat Chem Biol. 9(4):219-20.
  33. Serrage H , Heiskanen V , Palin WM , Cooper PR , Milward MR , Hadis M , Hamblin MR . Under the spotlight: mechanisms of photobiomodulation concentrating on blue and green light. Photochem Photobiol Sci. 2019 Aug 1;18(8):1877-1909. doi: 10.1039/c9pp00089e. Epub 2019 Jun 11. PMID: 31183484; PMCID: PMC6685747.
  34. de Freitas, L. F. & Hamblin, M. R. (2016) Proposed mechanisms of photobiomodulation or low-level light therapy. IEEE J. Sel. Topics Quantum Electron. 22, 7000417–7000434.
  35. Hamblin MR. (2017) Mechanisms and applications of the anti-inflammatory effects of photobiomodulation. AIMS Biophys. ;4(3):337-361.
  36. Buravlev et al. (2015) Are the mitochondrial respiratory complexes blocked by NO the targets for the laser and LED therapy? Lasers Med Sci, 30(1):173-180.
  37. Yara Cury, Gisele Picolo, Vanessa Pacciari Gutierrez, Sergio Henrique Ferreira, Pain and analgesia: The dual effect of nitric oxide in the nociceptive system,Nitric Oxide, Volume 25, Issue 3,2011,Pages 243-254.
  38. 38. Ruess et al. (2021) Blue-light treatment reduces spontaneous and evoked pain in a human experimental pain model Pain reports 6(4):p e968.
  39. 39. sagkaris C, Papazoglou AS, Eleftheriades A, Tsakopoulos S, Alexiou A, Găman MA, Moysidis DV. Infrared Radiation in the Management of Musculoskeletal Conditions and Chronic Pain: A Systematic Review. Eur J Investig Health Psychol Educ. 2022 Mar 14;12(3):334-343. doi: 10.3390/ejihpe12030024. PMID: 35323210; PMCID: PMC8946909.
  40. Lee et al. (2019) Far-infrared radiation stimulates platelet-derived growth factor mediated skeletal muscle cell migration through extracellular matrix-integrin signaling. Korean J. Physiol. Pharmacol. 23:141–150.
  41. Bundesamt fur Strahlenschutz [The German Federal Office for Radiation Protection], Applications of Infrared Radiation. 2020. [(accessed on 16 October 2021)].
  1. Understanding Pain – International Association for the Study of Pain
  2. IASP Fact Sheets on Low Back Pain
  3. Kokel et al. (2013) Photochemical activation of TRPA1 channels in neurons and animals. Nat Chem Biol. 2013 Apr;9(4):257-63.
  4. Serrage et al. (2019) Under the spotlight: mechanisms of photobiomodulation concentrating on blue and green light. Photochem Photobiol Sci. 18(8):1877-1909. 
  5. de Freitas & Hamblin (2016) Proposed mechanisms of photobiomodulation or low-level light therapy. IEEE J. Sel. Topics Quantum Electron. 22, 7000417–7000434.
  6. Hamblin MR. (2017) Mechanisms and applications of the anti-inflammatory effects of photobiomodulation. AIMS Biophys. 4(3):337-361.
  7. Buravlev et al. (2015) Are the mitochondrial respiratory complexes blocked by NO the targets for the laser and LED therapy? Lasers Med Sci, 30(1):173-180.
  8. Yara Cury, Gisele Picolo, Vanessa Pacciari Gutierrez, Sergio Henrique Ferreira, Pain and analgesia: The dual effect of nitric oxide in the nociceptive system,Nitric Oxide, Volume 25, Issue 3,2011,Pages 243-254.
  9. Ruess et al. (2021) Blue-light treatment reduces spontaneous and evoked pain in a human experimental pain model Pain reports 6(4):p e968.
  10. Sagkaris et al. (2022) Infrared Radiation in the Management of Musculoskeletal Conditions and Chronic Pain: A Systematic Review. Eur J Investig Health Psychol Educ. 14;12(3):334-343.
  11. Bundesamt fur Strahlenschutz [The German Federal Office for Radiation Protection], Applications of Infrared Radiation. 2020. (accessed on 16 October 2022)

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